An enhanced, highly temporally-spatially changing acoustic backscatter is highly correlated with the histotripsy process. Histotripsy induced tissue fragmentation is produced only when this acoustic backscatter pattern is observed. This highly variable acoustic backscatter is due to the sound reflection from the dynamically changing bubble cloud. It can be used as a real-time feedback for the histotripsy process.
References: Xu Z, JB Fowlkes, ED Rothman, AM Levin, and CA Cain. Controlled ultrasound
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microbubble activity. J Acoust Soc Am 2005; vol. 117: 424-435.