Histotripsy Group
    Biomedical Engineering Department, University of Michigan




Journal Publications

Conference Proceedings



Publications

Publications


2014

S. P. Allen, T. L. Hall, C. A. Cain, and L. Hernandez-Garcia, "Controlling cavitation-based image contrast in focused ultrasound in histotripsy surgery," Magnetic Resonance in Medicine, epub, 2014.


Y. Kim, E. Vlaisavljevich, G. E. Owens, S. P. Allen, C. A. Cain, and Z. Xu, "In vivo transcostal histotripsy therapy without aberration correction," Physics in Medicine and Biology, volume 59, pp. 2553-2568.


Y. Kim, T. L. Hall, Z. Xu, and C. A. Cain, "Transcostal histotripsy therapy: a feasibility study" IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, volume 61, number 4, pp. 582-593, 2014.


K.-W. Lin, Y. Kim, A. D. Maxwell, T.-Y. Wang, T. L. Hall, Z. Xu, J. B. Fowlkes, and C. A. Cain, "Histotripsy beyond the intrinsic cavitation threshold using very short ultrasound pulses: microtripsy," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, volume 61, number 2, pp. 251-265, 2014.


K.-W. Lin, A. P. Duryea, Y. Kim, T. L. Hall, Z. Xu, and C. A. Cain, "Dual-beam histotripsy: a low-frequency pump enabling a high-frequency probe for precise lesion formation," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, volume 61, number 2, pp. 325-340, 2014.


K.-W. Lin, T. L. Hall, R. J. McGough, Z. Xu, and C. A. Cain, "Synthesis of monopolar ultrasound pulses for therapy: the frequency-compounding transducer," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, volume 61, number 7, pp. 1123-1135, 2014.


W. W. Roberts, D Teofilovic, R. C. Jahnke, J. Patri, J. M. Risdahl, and J. A. Bertolina, "Histotripsy of the prostate using a commercial system in a canine model," Journal of Urology, volume 191, pp. 860-865, 2014.


G. R. Schade, N. R. Styn, K. A. Ives, T. L. Hall, W. W. Roberts, "Prostate histotripsy: evaluation of prostate urethral treatment parameters in a canine model," BJU International, volume 113, pp. 498-503, 2014.


E. Vlaisavljevich, Y. Kim, G. Owens, W Roberts, C. Cain, and Z. Xu, "Effects of tissue mechanical properties on susceptibility to histotripsy-induced tissue damage," Physics in Medicine and Biology, volume 59, pp. 253-270, 2014.


E. Vlaisavljevich, A. Maxwell, M. Warnez, E. Johnsen, C. A. Cain, and Z. Xu, "Histotripsy-induced cavitation cloud initiation thresholds in tissue of different mechanical properties," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, volume 61, number 2, pp. 341-352, 2014.


T.-Y. Wang, T. L. Hall, Z. Xu, J. B. Fowlkes, and C. A. Cain, "Image feedback for histotripsy by characterizing dynamics of acoustic radiation force impulse (ARFI)-induced shear wave excited in a treated volume," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, volume 61, number 7, pp. 1137-1151, 2014.

2013

C. L. Allam, J. E. Wilkinson, X. Cheng, K. A. Ives, T. L. Hall, and W. W. Roberts, "Histotripsy effects on the bladder trigone: functional and histological consequences in the canine model," Journal of Endourology, volume 27, number 10, pp. 1267-1271, 2013.


A. P. Duryea, W. W. Roberts, C. A. Cain, and T. L. Hall, "Controlled Cavitation to Augment SWL Stone Comminution: Mechanistic Insights In Vitro." IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 60(2), pp. 301-309, 2013.


J. M. Keller, G. R. Schade, K. Ives, X. Cheng, T. J. Rosol, M. Piert, J. Siddiqui, W. W. Roberts, and E. T. Keller, "A novel Canine Model for Prostate Cancer." The Prostate, vol. 73, pp. 952-959, 2013.


Y. Kim, C.G. Fifer, S. K. Gelehrter, G. E. Owens, D. R. Berman, E. Vlaisavljevich, S. P. Allen, M. F. Ladino-Torres MF, and Z. Xu, "Developmental Impact and Lesion Maturation of Histotripsy-Mediated Non-Invasive Tissue Ablation in a Fetal Sheep Model." Ultrasound Med. & Biol., vol. 39(6), pp. 1047-55, 2013.


A. D. Maxwell, C. A. Cain, T. L. Hall, J. B. Fowlkes, and Z. Xu, "Probability of Cavitation for Single Ultrasound Pulses Applied to Tissues and Tissue-Mimicking Materials." Ultrasound in Med. & Biol., vol. 39(3), pp. 449-465, 2013.


R. M. Miller, Y. Kim, K.-W. Lin, C. A. Cain, G. E. Owens, and Z. Xu, "Histotripsy cardiac therapy system integrated with real-time motion correction," Ultrasound in Medicine and Biology, volume 39, number 12, pp. 2362-2373, 2013.


S. Park, A. D. Maxwell, G. E. Owens, H. S. Gurm, C. A. Cain, and Z. Xu, "Non-invasive embolus trap using histotripsy - an acoustic parameter study," Ultrasound in Medicine and Biology, volume 39, number 4, pp. 611-619,2013.


E. Vlaisavljevich, Y. Kim, S. Allen, G. Owens, S. Pelletier, C. A. Cain, K. Ives, and Z. Xu, "Image-Guided Non-Invasive Ultrasound Liver Ablation using Histotripsy: Feasibility Study in an In Vivo Porcine Model." Ultrasound Med. & Biol., vol. 39(8), pp. 1398-409, 2013.


E. Vlaisavljevich, Y. Y. Durmaz, A Maxwell, M. ElSayed, and Z. Xu, "Nonodroplet-mediated histotripsy for image-guided targeted ultrasound cell ablation," Theranostics, volume 3, issue 11, pp. 851-864, 2013.

2012

G. E. Owens, R. M. Miller, S. T. Owens, S. D. Swanson, K. Ives, G Ensing, D. Gordon, and Z. Xu, "Intermediate-term effects of intracardiac communications created by noninvasively by therapeutic ultrasound (histotripsy) in a porcine model," Pediatric Cardiology, volume 33, pp. 83-89, 2012.


G. R. Schade, J. Keller, K. Ives, X. Cheng, T. J. Rosol, E. Keller, and W. W. Roberts, "Histotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model," Journal of Urology, volume 188, pp. 1957-1964, 2012.


G. R. Schade, N. R. Styn, T. L. Hall, and W. W. Roberts, "Endoscopic Assessment and Prediction of Prostate Urethral Disintegration After Histotripsy Treatment in a Canine Model." Journal of Endourology, vol. 26(2), pp. 183-189, 2012.


G. R. Schade, T. L. Hall, and W. W. Roberts, "Urethral-sparing Histotripsy of the Prostate in a Canine Model." Urology, vol. 80(2), pp. 730-735, 2012.


T.-Y. Wang, T. L. Hall, Z. Xu, J. B. Fowlkes, and C. A. Cain, "Imaging Feedback of Histotripsy Treatments Using Ultrasound Shear Wave Elastography." IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 59(6), pp. 1167-1181, 2012.


T.-Y. Wang, Z. Xu, T. L. Hall, F. B. Fowlkes, and C. A. Cain, "An Efficient Treatment Strategy for Histotripsy by Removing Cavitation Memory." Ultrasound in Med. & Boil., vol. 38(5), pp. 753-766, 2012.

2011

A. P. Duryea, T. L. Hall, A. D. Maxwell, Z. Xu, C. A. Cain, and W. W. Roberts, "Histotripsy Erosion of Model Urinary Calculi". Journal of Endourology, volume 25, number 2, pp. 341-344, 2011.


A. P. Duryea, A. D. Maxwell, W. W. Roberts, and Z. Xu, "In Vitro Comminution of Model Renal Calculi Using Histotripsy." IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 58(5), pp. 971-980, 2011.


C. R. Hempel, T. L. Hall, C. A. Cain, J. B. Fowlkes, Z. Xu, and W. W. Roberts, "Histotripsy fractionation of prostate tissue: Local effects and systemic response in a canine model." Journal of Urology, vol. 58(5), pp. 971-980, 2011.


Y. Kim, T.-Y. Wang, Z. Xu, and C. A. Cain, "Lesion generation through ribs using histotripsy therapy without aberration correction," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 58(11), pp. 2334-2343, 2011.


Y. Kim, S. K. Gelehrter, C. G. Fifer, J. C. Lu, G. E. Owens, D. R. Berman, J. Williams, J. E. Wilkinson, K. A. Ives, and Z. Xu, "Non-invasive pulsesd cavitational ultrasound for fetal tissue ablation: feasibility study in a fetal sheep model," Ultrasound in Obstetrics and Gynecology, volume 37, pp. 450-457, 2011.


A. D. Maxwell, G. Owens, H. S. Gurm, K. Ives, D. D. Myers, and Z. Xu, "Noninvasive Treatment of Deep Venous Thrombosis Using Pulsed Ultrasound Cavitation Therapy (Histotripsy) in a Procine Model." Laboratory Investigation, vol 22(3), pp. 369-377, 2011.


A. D. Maxwell, T.-Y. Wang, C. A. Cain, and J. B. Fowlkes, "Cavitation clouds created by shock scattering from bubbles during histotripsy." J. Acoust. Soc. Am., vol. 130(4), pp. 1888-1898, 2011.


G. E. Owens, R. M. Miller, G Ensing, K. Ives, D. Gordon, A. Ludomirsky, and Z. Xu, "Therapeutic ultrasound to noninvasively create intracardiac communications in an intact animal model," Catheterization and Cardiovascular Interventions, volume 77, pp. 580-588, 2011.


N .Styn, T. L. Hall, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Histortipsy Homogenization of the Prostate: Thresholds for Cavitation Damage of Periprostatic Structures." Journal of Endourology, vol. 25(9), pp. 1531-1535, 200.


T.-Y. Wang, Z. Xu, T. L. Hall, J. B. Fowlkes, W. W. Roberts, and C. A. Cain, "Active Focal Zone Sharpening for High-Precision Treatment Using Histotripsy." IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 58(2), pp. 305-315, 2011.


F. Winterroth, Z. Xu, T.-Y. Wang, J. E. Wilkinson, J. B. Fowlkes, W. W. Roberts, and C. A. Cain, "Examining and analyzing subcellular morphology of renal tissue treated by histotripsy". Ultrasound Med Biol, vol. 37(1), pp. 78-86, 2011.

2010

A. P. Duryea, T. L. Hall, A. D. Maxwell, Z. Xu, C. A. Cain, and W. W. Roberts, "Histotripsy Erosion of Model Urinary Calculi". J Endourol. 2010. (In Press)


T. L. Hall, C. R. Hempel, B. J. Sabb, and W. W. Roberts, "Acoustic access to the prostate for extracorporeal ultrasound ablation," J Endourol 24: 1875-81, 2010.


Y. Kim, S. K. Gelehrter, C. G. Fifer, J. C. Lu, G. E. Owens, D. R. Berman, J. Williams, J. E. Wilkinson, K. A. Ives, and Z. Xu, "Non-invasive pulsed cavitational ultrasound for fetal tissue ablation: feasibility study in a fetal sheep model". Ultrasound Obstet Gynecol. 2010. (In Press)


A. D. Maxwell, G. Owens, H. S. Gurm, K. Ives K, D. D. Myers, and Z. Xu, "Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model." J. Vasc. Interv. Radiol. 2010. (In Press)


A. D. Maxwell, T.-Y. Wang, L. Yuan, A. P. Duryea, Z. Xu, and C. A. Cain, "A tissue phantom for visualization and measurement of ultrasound-induced cavitation damage". Ultrasound Med Biol, vol. 36(12), pp. 2132-43, 2010.


G. E. Owens, R. M. Miller, G. Ensing, K. Ives, D. Gordon, A. Ludomirsky, and Z. Xu, "Therapeutic ultrasound to noninvasively create intracardiac communications in an intact animal model", Catheter Cardiovasc Interv. 2010 Sep 17.


N. R. Styn, J. C. Wheat, T. L. Hall, and W. W. Roberts, "Histotripsy of VX-2 tumor implanted in a renal rabbit model", J Endourol. 2010 Jul;24(7):1145-50.


J. C. Wheat, T. L. Hall, C. R. Hempel, C. A. Cain, Z. Xu, and W. W. Roberts, "Prostate histotripsy in an anticoagulated model," Urology 75: 207-11, 2010.


Z. Xu, G. Owens, D. Gordon, C. A. Cain, and A. Ludomirsky, "Non-invasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model," Circulation, vol. 121, pp. 742-749, 2010.

2009

T. L. Hall, C. R. Hempel, K. Wojno, Z. Xu, C. A. Cain, and W. W. Roberts, "Histotripsy of the prostate: dose effects in a chronic canine model," Urology., vol. 74, pp. 932-7., 2009.


A. D. Maxwell, C. A. Cain, A. Duryea, L. Yuan, H. S. Gurm, and Z. Xu, "Non-invasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy," Ultrasound in Med. & Biol., vol. 35, pp.1982-94, 2009.


T.-Y. Wang, Z. Xu, F. Winterroth, T. L. Hall, J. B. Fowlkes, E. D. Rothman, W. W. Roberts, and C. A. Cain, "Quantitative ultrasound backscatter for pulsed cavitational ultrasound therapy-histotripsy," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 56, pp. 995-1005, 2009.


Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, "Size Measurement of Tissue Debris Particles Generated from Mechanical Tissue Fractionation by Pulsed Cavitational Ultrasound Therapy - Histotripsy," Ultrasound in Medicine & Biology, vol. 35, pp. 245-255, 2009.

2008

A. M. Lake, T. L. Hall, K. Kieran, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Histotripsy: A minimally invasive technology for prostate tissue ablation in an in-vivo canine model," Urology, [E-publication ahead of print] Mar. 14, 2008.


A. M. Lake, Z. Xu, C. A. Cain, E. Wilkinson, and W. W. Roberts, "Renal ablation by histotripsy: Does it spare the collecting system?" J. Urol., vol. 179, pp. 1150-1154, 2008.


Z. Xu, M. Raghavan, T. L. Hall, M.-A. Mycek, J. B. Fowlkes, and C. A. Cain, "Evolution of bubble clouds produced in pulsed cavitational ultrasound therapy - histotripsy," IEEE Trans Ultrason Ferroelectr Freq Control., vol. 55, pp. 1122-1132, 2008.

2007

T. L. Hall, J. B. Fowlkes, and C. A. Cain, "A real-time measure of cavitation unduced tissue disruption by ultrasound imaging backscatter reduction," IEEE Trans Ultrasonics Ferroelectrics Freq Control, vol. 54, pp. 569-575, 2007.


T. L. Hall, K. Kieran, K. Ives, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Histotripsy of rabbit renal rissue in vivo: temporal histological trends," J. Endourol., vol. 21, pp. 1159-66, 2007.


K. Kieran, T. L. Hall, J. E. Parsons, J. S. Wolf Jr, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Refining histotripsy: Defining the parameter space for the creation of non-thermal lesions with high intensity pulsed ultrasound in the in vitro kidney," J. Urol., vol 178, pp. 672-676, 2007


J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, "Spatial variability in acoustic backscatter as an indicator of tissue homogenate production in pulsed cavitational ultrasound therapy," IEEE TransUltrasonics Ferroelectrics Freq Control, vol. 54, pp. 576-590, 2007.


Z. Xu, J. B. Fowlkes, and C. A. Cain, "Optical and acoustic monitoring of bubble cloud dynamics at a tissue-fluid interface in ultrasound tissue erosion,"Journal of the Acoustical Society of America., vol. 121, pp. 2421-2430, 2007.


Z. Xu, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Effects of acoustic parameters on bubble cloud dynamics in ultrasound tissue erosion (histotripsy)," Journal of the Acoustical Society of America, vol. 122, issue 1, pp.229-236, 2007.


Z. Xu, M. Raghavan, T. L. Hall, C.-W. Chang, M.-A. Mycek, J. B. Fowlkes, and C. A. Cain, "High speed imaging of bubble clouds generated in pulsed ultrasound cavitational therapy - histotripsy," IEEE Trans Ultrasonics Ferroelectrics Freq Control, vol. 54, issue 10, pp. 2091-2101, 2007.

2006

J. E. Parsons, C. A. Cain, and J. B. Fowlkes. "Cost-effective assembly of a basic fiber-optic hydrophone for measurement of high-amplitude therapeutic ultrasound fields," J. Acoust. Soc. Am., vol. 119, pp. 1432-40, 2006.


J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, "Pulsed cavitational ultrasound therapy for controlled tissue homogenization," Ultrasound in Med. & Biol., vol. 32, pp. 115-129, 2006.


W. W. Roberts, T. J. Hall, K. Ives, J. S. Wolf Jr., J. B. Fowlkes, and C. A. Cain, "Pulsed cavitational ultrasound : a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney," Journal of Urology, vol. 175, pp. 734-8, 2006.


Z. Xu, J. B. Fowlkes, and C. A. Cain, "A new strategy to enhance cavitational tissue erosion by using a high intensity initiating sequence," IEEE Trans Ultrasonics Ferroelectrics Freq Control, vol. 53, pp. 1412-1424, 2006.

2005

J. Seo, B. C. Tran, T. J. Hall, J. B. Fowlkes, G. D. Abrams, M. O'Donnell, and C. A. Cain, "Evaluation of Ultrasound Tissue Damage Based on Changes in Image Echogenicity," IEEE Trans Ultrasonics Ferroelectrics Freq Control, vol. 52, pp. 1111-1120, 2005.


J. Seo, J. J. Choi, J. B. Fowlkes, and C. A. Cain, "Aberration correction by nonlinear beam-mixing: generation of a pseudo point sound source," IEEE Trans Ultrasonics Ferroelectrics Freq Control, vol. 52, pp. 1970-80, 2005.


B. C. Tran, J. Seo, T. J. Hall, J. B. Fowlkes, and C. A. Cain, "Effects of contrast agent infusion rates on thresholds for tissue damage produced by single exposures of high-intensity ultrasound," IEEE Trans Ultrasonics Ferroelectrics Freq Control, vol. 52, pp. 1121-1130, 2005.


W. W. Roberts, "Use of novel energy sources in the treatment of urological cancers," Urol. Oncol., vol. 23, p. 354, 2005.


W. W. Roberts, "Focused ultrasound ablation of renal and prostate cancer: Current technology and future directions," Urol. Oncol., vol. 23, pp. 367-371, 2005.


Z. Xu, J. B. Fowlkes, E. D. Rothman, A. M. Levin, and C. A. Cain, "Controlled Ultrasound Tissue Erosion: the role of dynamic interaction between insonation and microbubble activity," Journal of the Acoustical Society of America, vol. 117, pp. 424-435, 2005.


Z. Xu, J. B. Fowlkes, A. Ludomirsky, and C. A. Cain, "Investigation of intensity threshold for ultrasound tissue erosion," Ultrasound in Med. & Biol., vol. 31, pp. 1673-1682, 2005.


2003 - 2004

Z. Xu, A. Ludomirsky, L. Y. Eun, T. L. Hall, B. C. Tran, J. B. Fowlkes, and C. A. Cain, "Controlled ultrasound tissue erosion," IEEE Transaction on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 51, pp. 726-736, 2004.


B. C. Tran, J. Seo, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Microbubble-enhanced cavitation for noninvasive ultrasound surgery," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 50, pp. 1296-1304, 2003.




Conference Proceedings


2013

A. P. Duryea, C. A. Cain, W. W. Roberts, H. A. Tamaddoni, T. L. Hall, "Active removal of a residual bubble nuclei following a cavitation event," Proc. IEEE Ultrasonics Symposium, pp. 1813-1816, 2013.


Y. Kim, E. Vlaisavljevich, G. Owens, S. Allen, C. A. Cain, and Z. Xu, "In Vivo Transcostal Histotripsy Therapy without Aberration Correction," Proc. IEEE Ultrasonics Symposium, pp. 1817-1820, 2013.


R. M. Miller, X. Chang, A. D. Maxwelll, T.-Y. Wang, J. B. Fowlkes, C. A. Cain, and Z. Xu, "Investigation of the mechanism of ARFI-based color Doppler feedback of histotripsy tissue fractionation," Proc. IEEE Ultrasonics Symposium, pp. 934-937, 2013.


E. Vlaisavljevich, Y. Y. Durmaz, A. Maxwell, M. El-Sayed, and Z. Xu, "Nanodroplet-Mediated Histotripsy Ultrasound Therapy for Targeted Cancer Ablation," presented in 2013 IEEE International Ultrasonics Symposium, Prague, Czech Republic, July 21-25, 2013.

2012

A. P. Duryea, W. W. Roberts, C. A. Cain, and T. L. Hall, "Optically Triggered Solid State Driver for Shock Wave Therapy," 11th International Symposium on Therapeutic Ultrasound, pp. 76-80, 2012.


A. P. Duryea, W. W. Roberts, C. A. Cain, and T. L. Hall, "Controlled Cavitation to Augment SWL Stone Subdivision: Mechanistic Insights In-Vivo," Proc. IEEE Ultrasonics Symposium, pp. 2603-2606, 2012.


K.-W. Lin, T.-Y. Wang, T. L. Hall, C. A. Cain, D. A. Merton, F. Forsberg, B. B. Goldberg, and J. B. Fowlkes, "Noninvasive Approach for Metastatic Lymph Node Ablation using Histotripsy Tissue Fractionation," Proc. IEEE International Ultrasonics Symposium, pp. 1007-1010, 2012.


R. M. Miller, A. D. Maxwell, T.-Y. Wang, J. B. Fowlkes, C. A. Cain, and Z. Xu, "Real-time elastography-based monitoring of histotripsy tissue fractionation using color doppler," Proc. IEEE Ultrasonics Symposium, pp. 196-199, 2012.


E. Vlaisavljevich, Y. Kim, S. Allen, G. Owens, S. Pelletier, K. Ives, and Z. Xu, "Image-Guided Non-Invasive Ultrasound Liver Ablation using Histotripsy: Feasibility Study in an in vivo Porcine Model," presented in 2012 IEEE International Ultrasonics Symposium, Dresden, Germany, October 7-10, 2012.

2011

Y. Kim, C. Fifer, S. Gelehrter, G. Owens, E. Vlaisavljevich, C. Cain, and Z. Xu, "Non-invasive fetal therapy using histotripsy: safety and local impact on fetal development," Proc. IEEE Ultrasonics Symposium, pp. 1874-1877, 2011.


K.-W. Lin, T.-Y. Wang, R. E. Kumon, C. X. Deng, Z. Xu, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Ultrasound Backscatter Spectrail Analysis Provides Image Feedback for Histotripsy Tissue Fracntionation," Proc. IEEE International Ultrasonics Symposium, pp. 33-36, 2011.


A. D. Maxwell, S. Park, C. A. Cain, and Z. Xu, "Trapping of solid particles by cavitation-induced acoustic streaming," Proc. IEEE Ultrasonics Symposium, pp. 1506-1509, 2011.


R. M. Miller, Y. Kim, K.-W. Lin, G. Owens, C. A. Cain, and Z. Xu, "Real-time motion tracking for non-invasive ultrasound cardiac therapy using histotripsy," presented in Proc. IEEE Ultrasonics Symposium, pp. 935-938, 2011.


S. Park, A. D. Maxwell, G. Owens, H. S. Gurm, C. A. Cain, and Z. Xu, "The effect of acoustic parameters on the non-invasive embolus trap (NET) using a histotripsy-generated bubble cloud," Proc. IEEE Ultrasonics Symposium, pp. 1878-1881, 2011.


A. P. Duryea, W. W. Roberts, C. A. Cain, and T. L. Hall, "Optically Triggered Solid State Driver for Shock Wave Therapy," presented in 2011 IEEE International Ultrasonics Symposium, Orlando, FL, October 18-21, 2011.


E. Vlaisavljevich, C. A. Cain, and Z. Xu, "Effect of Histotripsy on Tissues with Different Mechanical Properties," presented in 2011 IEEE International Ultrasonics Symposium, Orlando, FL, October 18-21, 2011. 2011.


T.-Y. Wang, T. L. Hall, Z. Xu, J. B. Fowlkes, and C. A. Cain, "Image feedback of histotripsy treatments using ultrasound transient elastography," Proc. IEEE Ultrasonics Symposium, pp. 2233-2236, 2011.

2010

A. P. Duryea, W. W. Roberts, C. A. Cain, and T. L. Hall, "Optimization of Histotripsy for Kidney Stone Erosion," presented in 2010 IEEE Ultrasonics Symposium, 5A-5, San Diego, CA, Oct. 11-14, 2010.


Y. Kim, T.-Y. Wang, Z. Xu, and C. A. Cain, "Lesion Generation through Ribs without Aberration Correction using Cavitational Therapy," presented in 2010 IEEE Ultrasonics Symposium, 5A-6, San Diego, CA, Oct. 11-14, 2010.


K.-W. Lin, X. Shao, Z. Xu, J. B. Fowlkes, and C. A. Cain, "Ultrasound-Induced Fluid Uptake Phenomenon in Porcine Uterine Tissue," presented in 2010 IEEE Ultrasonics Symposium, 5A-4, San Diego, CA, Oct. 11-14, 2010.


R. M. Miller, G. Owens, G. Ensing, A. Ludomirsky, C. A. Cain, Z. Xu, "Histotripsy for Pediatric Cardiac Applications: In Vivo Neonatal Pig Model," 9th International Symposium on Therapeutic Ultrasound, pp 15-18, 2010.


A. D. Maxwell, C. A. Cain, J. B. Fowlkes, and Z. Xu, "Inception of Cavitation Clouds by Scattered Shockwaves," presented in 2010 IEEE Ultrasonics Symposium, , 3B-2, San Diego, CA, Oct. 11-14, 2010.


A. D. Maxwell, T.-Y. Wang, L. Yuan, A. Duryea, Z. Xu, and C. A. Cain, "A Tissue Phantom for Evaluation of Mechanical Damage Caused by Cavitation," 9th International Symposium on Therapeutic Ultrasound, pp 31-35, 2010.


T.-Y. Wang, T. L. Hall, Z. Xu, J B. Fowlkes, and C. A. Cain, "Local cavitation suppression using cavitation nuclei preconditioning for precise treatment in histotripsy," presented in 2010 IEEE Ultrasonics Symposium, 5A-3, San Diego, CA, Oct. 11-14, 2010.


T.-Y. Wang, A. D. Maxwell, S. P., Z. Xu, J. B. Fowlkes, and C. A. Cain, "Why Are Short Pulses More Efficient in Tissue Erosion Using Pulsed Cavitational Ultrasound Therapy (Histotripsy)?," 9th International Symposium on Therapeutic Ultrasound, pp 40-43, 2010.


2009

A. Duryea, A. D. Maxwell, W. Roberts, Z. Xu, T. L. Hall, and C. A. Cain, "Non-invasive Comminution of Renal Calculi Using Pulsed Cavitational Ultrasound Therapy - Histotripsy," Proc. IEEE Ultrasonics Symposium, pp.73-76, 2009.


Y. Kim, C. G. Fifer, S. K. Gelehrter, J. Williams, J. C. Lu, C. A. Cain, and Z. Xu, "Non-invasive Fetal Therapy using Histotripsy: Feasibility Study in the Sheep Model" Proc. IEEE Ultrasonics Symposium, pp. 228-231, 2009.


A. D. Maxwell, G. Owens, H. S. Gurm, C. A. Cain, and Z. Xu, "In-Vivo Study of Non-Invasive Thrombolysis by Histotripsy in a Porcine Model," Proc. IEEE Ultrasonics Symposium, pp. 220-223, 2009.


A. D. Maxwell, T.-Y. Wang, C. A. Cain, J. B. Fowlkes, O. A. Sapozhnikov, M. R. Bailey, and Z. Xu, "The Role of Compressional Pressure in the Formation of Dense Bubble Clouds in Histotripsy," Proc. IEEE Ultrasonics Symposium, pp. 81-84, 2008.


A. D. Maxwell, T.-Y. Wang, L. Yuan, A. Duryea, Z. Xu, and C. A. Cain, "A Tissue Phantom for Evaluation of Mechanical Damage Caused by Cavitation," 9th International Symposium on Therapeutic Ultrasound, pp 31-35, 2009.


R. M. Miller, G. Owens, G. Ensing, A. Ludomirsky, C. A. Cain, Z. Xu, "Histotripsy for Pediatric Cardiac Applications: In Vivo Neonatal Pig Model," 9th International Symposium on Therapeutic Ultrasound, pp 15-18, 2009.


W. W. Roberts, A. M. Lake, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Histotripsy of the prostate in a canine model: Non-invasive non-thermal tissue debulking," 7th International Symposium on Therapeutic Ultrasound, 2008. (In Press)


T.-Y. Wang, A. D. Maxwell, S. P., Z. Xu, J. B. Fowlkes, and C. A. Cain, "Why Are Short Pulses More Efficient in Tissue Erosion Using Pulsed Cavitational Ultrasound Therapy (Histotripsy)?," 9th International Symposium on Therapeutic Ultrasound, pp 40-43, 2009.


T.-Y. Wang, Z. Xu, T. L. Hall, J B. Fowlkes, W. W. Roberts, and C. A. Cain, "Active Protection in Pulse Cavitational Ultrasound Therapy (Histotripsy)," Proc. IEEE Ultrasonics Symposium, pp. 212-215, 2009.


2008

T. L. Hall, C. R. Hempel, A. M. Lake, K. Kieran, K. Ives, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Histotripsy for the treatment of BPH: evaluation in a chronic canine model," Proc. IEEE Ultrasonics Symposium, pp.765-767, 2008.


A. D. Maxwell, C. A. Cain, H. S. Gurm, J. B. Fowlkes, and Z. Xu., "Non-Invasive Thrombolysis Induced by Histotripsy Pulsed Cavitation Ultrasound Therapy," Proc. IEEE Ultrasonics Symposium, pp.1167-1170, 2008.


W. W. Roberts, A. M. Lake, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Histotripsy of the prostate in a canine model: Non-invasive non-thermal tissue debulking," 7th International Symposium on Therapeutic Ultrasound, 2008. (In Press)


T.-Y. Wang, Z. Xu, F. Winterroth, T. L. Hall1, J B. Fowlkes, E. D. Rothman, W. W. Roberts, and C A. Cain, "Quantitative Image Feedback for Pulsed Cavitational Ultrasound Therapy- Histotripsy," Proc. IEEE Ultrasonics Symposium , pp. 867-870, 2008.


2007

J. B. Fowlkes, "Applications of Bubbles in Ultrasonic Therapy," presented at International symposium on therapeutic ultrasound, OS05_1, Seoul, Korea, Jun 12-15 2007.


T. L. Hall, K. Kieran, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Temporal trends in the histology of the rabbit kidney after cavitational tissue ablation," 6th International Symposium on Therapeutic Ultrasound, pp. 191-197, 2007.


T. L. Hall, G. R. Lee, L. Hernandez, and C. A. Cain, "Relaxation Properties of Cavitation Induced Tissue Lesions," Poster at Joint Annual Meeting ISMRM (International Society for Magnetic Resonance in Medcine)-ESMRMB (European Society for Magnetic Resonance in Medicine and Biology), pp. 1118, May 19-25 2007.


K. Kieran, T. L. Hall, J. E. Parsons, J. S. Wolf Jr., J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Exploring the acoustic parameter space in ultrasound therapy: Defining the threshold for cavitational effects," 6th International Symposium on Therapeutic Ultrasound, pp. 185-190, 2007.


A. Lake et al, "Cavitational Ultrasound: A Potential Minimally Invasive Therapy for BPH," Poster at American Urological Association annual meeting, Anaheim, CA, May 23, 2007.


A. Lake et al, "Histotripsy Threshold of Various Renal Tissues in Porcine Kidney," Poster at Engineering and Urology Society submeeting at the American Urological Association annual meeting, Anaheim, CA, May 19, 2007.


W. W. Roberts, A. M. Lake, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Histotripsy of the prostate in a canine model: non-invasive non-thermal tissue debulking," Presented at International symposium on therapeutic ultrasound, OS05_4, Seoul, Korea, Jun 12-15 2007.


F. Winterroth, Z. Xu, T.-Y. Wang, W. W. Roberts, J. B. Fowlkes, and C. A. Cain, "Tissue Fragmentation Treatment by Pulsed Cavitational Ultrasound Therapy-Histotripsy," presented at 13th International Symposium on Applied Electromagnetics and Mechanics (ISEM), East Lansing, MI, USA, 9-12 Sep 2007.


Z. Xu, M. Raghavan, T. L. Hall, M.-A. Mycek, J. B. Fowlkes, and C. A. Cain, "Evolution of bubble clouds produced in pulsed cavitational ultrasound therapy - histotripsy," Poster at International symposium on therapeutic ultrasound, pp. PS02_1, Seuol, Korea, Jun 12-15 2007.


2006

C. A. Cain, "Histotripsy: controlled mechanical sub-division of soft tissues by high intensity pulsed ultrasound," Invited talk IEEE International Ultrasonics Symposium, 1D-1, 2006.


K. Kieran, T. L. Hall, J. E. Parsons, J. S. Wolf, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Exploring the Acoustic Parameter Space in Ultrasound Therapy: Defining the Threshold for Cavitational Effects," 6th International Symposium on Therapeutic Ultrasound, pp. S01, 2006.


T. L. Hall, K. Kieran, J. B. Fowlkes, C. A. Cain, and W. W. Roberts, "Temporal trends in the histology of the rabbit kidney after cavitational tissue ablation," 6th International Symposium on Therapeutic Ultrasound, pp. S07, 2006.


Z. Xu, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Size measurement of tissue debris generated from mechanical tissue fractionation by cavitational pulsed ultrasound therapy - histotripsy," 6th International Symposium on Therapeutic Ultrasound, pp. O60, 2006.


Z. Xu, M. Raghavan, T. L. Hall, C.-W. Chang, M.-A. Mycek, J. B. Fowlkes, and C. A. Cain, "High Speed Imaging of Bubble Cloud in Pulsed Cavitational Ultrasound Therapy - Histotripsy," Proc. IEEE International Ultrasonics Symposium, pp. 1D-4, 2006.


2005

C. A. Cain, "Histotripsy: controlled mechanical sub-division of soft tissues by high intensity pulsed ultrasound," International symposium on therapeutic ultrasound, pp. T005, 2005.


J. B. Fowlkes, O. D. Kripfgans, and A. M. Lo, "Production and use of microbubbles in therapeutic ultrasound," International symposium on therapeutic ultrasound, pp. T006, 2005.


T. J. Hall and C. A. Cain, "A Low cost, compact, 512 channel therapeutic system for transcutaneous ultrasound surgery," International symposium on therapeutic ultrasound, pp. S035, 2005.


J. E. Parsons, J. B. Fowlkes, and C. A. Cain, "Acoustic backscatter features associated with production of tissue homogenate using pulsed cavitational ultrasound therapy," International symposium on therapeutic ultrasound, pp. S024, 2005.


Z. Xu, J. B. Fowlkes, and C. A. Cain, "Optical and acoustic monitoring of bubble dynamics at a tissue-fluid interface in ultrasound tissue erosion," International symposium on therapeutic ultrasound, pp. S03, 2005.


2004

M. Cooper, Z. Xu, E. D. Rothman, A. M. Levin, A. P. Advincula, J. B. Fowlkes, and C. A. Cain, "Controlled Ultrasound Tissue Erosion: the Effects of Tissue Type, Exposure Parameters and the Role of Dynamic Microbubble Activity," Proc. 2004 IEEE International Ultrasonics, Ferroelectric, and Frequency Control Joint 50th Anniversary Conference, vol. 3, pp. 1808-11, 2004.


J. E. Parsons, C. A. Cain, and J. B. Fowlkes, "Characterizing pulsed ultrasound therapy for the production of cavitational lesions," Proc. 4th Int. Symp. Therapeutic Ultrasound, AIP conf. Proc. 754, pp. 178-180, 2004.


B. C. Tran, J. B. Fowlkes, and C. Cain, "Correlation between acoustic backscatter variability and tissue damage prodcued by pulses cavitational ultrasound therapy," Proc. 2004 IEEE International Ultrasonics, Ferroelectric, and Frequency Control Joint 50th Anniversary Conference, vol. 2, pp. 1461-4, 2004.


2003


B. C. Tran, J. Seo, T. L. Hall, Z. Xu, K. Ives, J. B. Fowlkes, and C. A. Cain, "In vivo Comparison of Multiple Pulse and CW strategies for Microbubble-Enhanced Ultrasound Therapy.," Proc. IEEE Ultrasonics Symposium, pp. 909-912, 2003.


Z. Xu, A. Ludomirsky, L. Y. Eun, T. L. Hall, B. C. Tran, J. B. Fowlkes, and C. A. Cain, "Cavitional Tissue Erosion by Therapeutic Ultrasound," Proc. Modelling and Experimental Measurements in Acoustics III, pp. 411-421, 2003.


Z. Xu, A. Ludomirsky, L. Y. Eun, T. L. Hall, B. C. Tran, J. B. Fowlkes, and C. A. Cain, "Controlled Ultrasound Tissue Erosion," Proc. 2003 IEEE Ultrasonics Symposium, pp. 732-735, 2003.


2000 - 2002

J. Seo, B. C. Tran, T. L. Hall, J. B. Fowlkes, M. O'Donnell, and C. A. Cain, "Evaluation of tissue damage based on changes in echogenicity," Proc. 2002 IEEE Ultrasonics Symposium, vol. 2, pp. 1431-4, 2002.


B. C. Tran, J. Seo, J. B. Fowlkes, and C. A. Cain, "The effect of microbubble concentration on thresholds for tissue damage produced by single bursts of high intensity ultrasound during continuous optison infusion," Proc. 2002 IEEE Ultrasonics Symposium, vol. 2, pp. 1411-1414, 2002.


B. C. Tran, J. Seo, J. B. Fowlkes, and C. A. Cain, "Microbubble enhanced threshold reductions for tissue damage using high Intensity ultrasound," Proc. IEEE Ultrasonics Symposium, vol. 2, pp. 1389-1392, 2001.


B. C. Tran, T. L. Hall, J. B. Fowlkes, and C. A. Cain, "Noninvasive ultrasound surgery: role of microbubble enhanced cavitation," Proc. 2000 IEEE Ultrasonics Symposium, vol. 2, pp. 1425-1428, 2000.