Histotripsy Group
    Biomedical Engineering Department, University of Michigan

Research -> Measurements of Debris Generated by Histotripsy

Measurements of Debris Generated by Histotripsy


There is a concern that particles generated from erosion at a tissue-fluid interface by histotripsy might be an embolization hazard. Therefore, it is essential to measure the size distribution of these tissue particles. For bulk tissue treatment, measurement of particles inside the lesion may help understand the mechanism of histotripsy. Tissue debris created by histotripsy induced erosion at a tissue-fluid interface and inside lesions in bulk tissue was collected and measured with a particle sizing system (Multisizer 3, Beckman Coulter, CA USA). In resulting samples, all tissue particles were found to be smaller than 40μm. Debris smaller than 6μm constitutes >99% of the total number of tissue debris particles. Over 90% of the total number of residual particles was found to be smaller than 2μm, which was unlikely to be an embolization hazard.

References:
Xu Z, Hall TL, Fowlkes JB, Cain CA, "Size measurement of tissue debris generated from mechanical tissue fractionation by cavitational pulsed ultrasound therapy - histotripsy," 6th International Symposium on Therapeutic Ultrasound, O60 (2006).