Significant reduction in speckle amplitude within the treated region is observed in B-mode ultrasound imaging after the histotripsy treatment.
Sample B-scan images before and after treatment and corresponding histograms for the treatment area ROI indicated by the square. B-scan images are displayed on a 60 dB dynamic range scale. The significant echogenicity change is caused by a shift in the backscatter amplitude distribution.
References: Hall TL, Fowlkes JB, Cain CA, "Imaging feedback of tissue liquefication (Histotripsy) in ultrasound surgery," Proc. international 2005 IEEE Ultrasonics Symposium 3, 1732-1734 (2005).
Hall TL, Fowlkes JB, Cain CA, "A real-time measure of cavitation unduced
tissue disruption by ultrasound imaging backscatter reduction," IEEE
Trans. Ultrason. Ferroelectr. Freq. Control 54, 569-575 (2007).