Histotripsy Mechanism

We believe acoustic cavitation is the primary mechanics for histotirpsy. Acoustic cavitation is a phenomenon where rapid cycling of acoustic pressure from compression to rarefaction results in formation of microbubbles within the tissue. These bubbles have been observed to oscillate and violently collapse releasing tremendous energy. The net effect of cavitation is localized stresses and pressures that can mechanically fragment and subdivide the tissue resulting in cellular destruction. 

Our working hypothesis to explain the mechanism is: each histotripsy pulse creates a localized highly dynamic cluster of microbubbles, whose energetic interaction with tissue produces a fraction of the required tissue fragmentation, and provides seeds to subsequent pulses for bubble regeneration. 
For further information about our research on histotripsy mechanism, please click on High Speed ImagingAcoustic Monitoring, and Optical Monitoring