Journal Publications (2015 ~ Present)


Shi A, Xu Z, Lundt J, Tamaddoni HA, Worlikar T, Hall TL. “Integrated Histotripsy and Bubble Coalescence Transducer for Rapid Tissue Ablation“. IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Jul 23. doi: 10.1109/TUFFC.2018.2858546. [Epub ahead of print] PubMed PMID: 30040636.

Schuster TG, Wei JT, Hendlin K, Jahnke R, Roberts WW. Histotripsy Treatment of Benign Prostatic Enlargement Using the Vortx R(x) System: Initial Human Safety and Efficacy Outcomes. Urology. 2018 Apr;114:184-187. doi: 10.1016/j.urology.2017.12.033. Epub 2018 Jan 9. PubMed PMID: 29330000.

Gerhardson T, Sukovich JR, Pandey AS, Hall TL, Cain CA, Xu Z. Catheter Hydrophone Aberration Correction for Transcranial Histotripsy Treatment of Intracerebral Hemorrhage: Proof-of-Concept. IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Nov;64(11):1684-1697. doi: 10.1109/TUFFC.2017.2748050. Epub 2017 Aug 31. PubMed PMID: 28880166; PubMed Central PMCID: PMC5681355.

Gerhardson T, Sukovich JR, Pandey AS, Hall TL, Cain CA, Xu Z. Effect of Frequency and Focal Spacing on Transcranial Histotripsy Clot Liquefaction, Using  Electronic Focal Steering. Ultrasound Med Biol. 2017 Oct;43(10):2302-2317. doi: 10.1016/j.ultrasmedbio.2017.06.010. Epub 2017 Jul 14. PubMed PMID: 28716432; PubMed Central PMCID: PMC5580808.

Zhang X, Macoskey JJ, Ives K, Owens GE, Gurm HS, Shi J, Pizzuto M, Cain CA, Xu Z. Non-Invasive Thrombolysis Using Microtripsy in a Porcine Deep Vein Thrombosis Model. Ultrasound Med Biol. 2017 Jul;43(7):1378-1390. doi: 10.1016/j.ultrasmedbio.2017.01.028. Epub 2017 Apr 28. PubMed PMID: 28457630; PubMed Central PMCID: PMC5440202.

Macoskey, Jonathan J. et al. “Bubble-Induced Color Doppler Feedback Correlates with Histotripsy-Induced Destruction of Structural Components in Liver Tissue.” Ultrasound in Medicine & Biology 44.3 (2018): 602-612,

Macoskey, Jonathan J. et al. “Using the cavitation collapse time to indicate the extent of histotripsy-induced tissue fractionation.” Physics in Medicine & Biology 63.5 (2018)

Macoskey, Jonathan J. et al. “Soft-Tissue Aberration Correction for Histotripsy.” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 65.11 (2018)


Lundt, Jonathan E. et al. “Non-invasive, Rapid Ablation of Tissue Volume Using Histotripsy.” Ultrasound in Medicine & Biology 43.12 (2017): 2834-2847.

Allen, Steven et al. “The response of MRI contrast parameters in in vitro tissues and tissue mimicking phantoms to fractionation by histotripsy.” Physics in medicine and biology 62.17(2017):7167.

Macoskey, Jonathan et al. “Real-time acoustic-based feedback for histotripsy therapy.” The Journal of the Acoustical Society of America 141, 3551 (2017).

Sukovich, Jonathan et al. “Transcranial histotripsy acoustic-backscatter localization and aberration correction for volume treatments.” The Journal of the Acoustical Society of America 141, 3490 (2017)

Vlaisavljevich, Eli et al. “Non-Invasive Liver Ablation Using Histotripsy: Preclinical Safety Study in an In Vivo Porcine Model.” Ultrasound in Medicine and Biology 43.6 (2017): 1237-1251


Miller, Ryan M. et al. “Bubble-Induced Color Doppler Feedback for Histotripsy Tissue Fractionation.” IEEE transactions on ultrasonics, ferroelectrics, and frequency control 63.3 (2016): 408–419.

Sukovich, Jonathan et al. “Histotripsy pulse-reflection for 3D image forming and bubble cloud localization in transcranial applications.” The Journal of the Acoustical Society of America 140, 3083 (2016)

Cain, Charles et al. “Histotripsy: Transcranial applications.”The Journal of the Acoustical Society of America 140, 3030 (2016)


Zhang, Xi et al. “Real-Time Feedback of Histotripsy Thrombolysis Using Bubble-Induced Color Doppler.” Ultrasound in medicine & biology 41.5 (2015): 1386–1401. PMC. Web. 1 June 2018. 

Vlaisavljevich, Eli et al. “Effects of Tissue Stiffness, Ultrasound Frequency, and Pressure on Histotripsy-Induced Cavitation Bubble Behavior.” Physics in medicine and biology 60.6 (2015): 2271–2292. 

Khokhlova, VA et al. “Histotripsy Methods in Mechanical Disintegration of Tissue: Toward Clinical Applications.” International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 31.2 (2015): 145–162. 

Devanagondi, Rajiv et al. “Hemodynamic and Hematologic Effects of Histotripsy of Free-Flowing Blood: Implications for US-Mediated Thrombolysis.” Journal of vascular and interventional radiology : JVIR 26.10 (2015): 1559–1565.

Vera A. Khokhlova, J. Brian Fowlkes, William W. Roberts, George R. Schade, Zhen Xu, Tatiana D. Khokhlova, Timothy L. Hall, Adam D. Maxwell, Yak-Nam Wang & Charles A. Cain (2015) Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications, International Journal of Hyperthermia, 31:2, 145-162, DOI: 10.3109/02656736.2015.1007538
 Duryea AP; Roberts WW; Cain CA; Hall TL. “Removal of residual cavitation nuclei to enhance histotripsy erosion of model urinary stones.”  IEEE Trans Ultrason Ferroelectr Freq Control. 62(5):896-904, 2015 May.